产品货号：
Z16484
中文名称：
ESRRG抗体
英文名称：
Anti-ESRRG Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ESRRG Antibody |
| 指标别名 | ERR gamma 2;ERR3;ERRG2;ERRgamma;ESRRG;estrogen related receptor gamma;KIAA0832;NR3B3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC/IF,FCM,ELISA |
| 基因名称 | ESRRG |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human ESRRG recombinant protein (Position:Q302-V458). |
| 实际分子量 | 51KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Estrogen-related receptor gamma (ERR-gamma),also known as NR3B3,is a nuclear receptor that in humans is encoded by the ESRRG gene.This gene encodes a member of the estrogen receptor-related receptor (ESRR) family,which belongs to the nuclear hormone receptor superfamily.All members of the ESRR family share an almost identical DNA binding domain,which is composed of two C4-type zinc finger motifs.The ESRR members are orphan nuclear receptors;they bind to the estrogen response element and steroidogenic factor 1 response element,and activate genes controlled by both response elements in the absence of any ligands.The ESRR family is closely related to the estrogen receptor (ER) family.They share target genes,co-regulators and promoters,and by targeting the same set of genes,the ESRRs seem to interfere with the ER-mediated estrogen response in various ways.It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters,modulates cell proliferation and estrogen signaling in breast cancer,and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation.Multiple alternatively spliced transcript variants have been identified,which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. |
| Uniprot ID | P62508 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section 1:50～400 Immunocytochemistry in fixed cells 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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